Mice tolerated the daily thapsigargin exposure regimen for at least three weeks without any apparent ill effects. There was no indication of respiratory distress, neuromuscular abnormality, ...

We hypothesize that oxidative stress and a loss of calcium homeostasis are common features that underlie the pathology of different LSDs, 16, 17 such as NPA, even though the specific underlying ...

Our cells move energy and matter to the places it is needed. But how do they do this in real time, and seen from the perspective of a single molecule? Scientists have successfully uncovered new basic ...

Like entrance and exit doors on a building, a cell's outer surface has doors -- channels, pumps, and transporters that selectively control what molecules enter or exit. In the immune system, T cells ...

A key abnormality in heart failure is defective handling of calcium ions by cardiomyocytes. In the healthy heart, the action potential leads to an increase in the level of intracellular calcium (and ...

Boston, MA - The improvement of intracellular calcium cycling, through overexpression of the sarcoplasmic reticulum CA 2+ ATPase pump (SERCA2a), reduces arrhythmias and restores contractile function ...

We evaluated a family in which five siblings were affected by autosomal recessive sensorineural hearing loss. Despite the presumably shared cause of the disorder, there were clinically significant ...

Widely known for their pivotal role in producing the amyloid-β peptides regarded as pathological hallmarks of Alzheimer disease, presenilins may now have a new claim to fame. A paper in the 30 June ...