After Jonathan Violin completed his Ph.D. at the University of California, San Diego, he wanted to continue his research with a high-profile scientist working on G-protein-coupled receptors (GPCRs).

NEW YORK, NY (April 27, 2022)--Roughly a third of all drugs approved by the U.S. Food and Drug Administration target a large family of biomolecules, known as G protein-coupled receptors (GPCRs), whose ...

Using advanced imaging methods, researchers have gained insight into how a common target of drugs sends cellular signals, a finding that may lead to better and more precise therapeutics. Roughly a ...

Emerging Tools and Methodologies for Screening and Discovery Are Improving Odds for Success In the organism, communication occurs at both the macro and the micro level. At the micro level—inside the ...

Just Because a G-Protein Coupled Receptor Has Resisted Characterization Doesn’t Mean It Can’t Be Sighted—or Hunted For drug developers, G-protein coupled receptors (GPCRs) are dearly sought trophies.

There are many and various receptors on the surface of each human cell, which bind to specific molecules called ligands, to set off signals that modulate cell activity accordingly. These pathways are ...

SEATTLE--(BUSINESS WIRE)--Omeros Corporation (Nasdaq: OMER) today announced a new approach to cancer immunotherapy that targets inhibition of GPR174, a member of the family of G protein-coupled ...

PIP2 is an important phosphoinositide that is present in around 1% of the plasma membrane. It is also involved in signal transduction of intracellular and extracellular components. There are two ...