The intracellular environment is highly compartmentalized; biomolecules (nucleic acids, proteins, lipids and so on) are spatiotemporally organized to form functional modules, signal pathways and ...

Endosomal and cytosolic nucleic acid receptors sense microbial nucleic acids and initiate innate immune responses. However, in some circumstances their activation by endogenous nucleic acids can also ...

Nucleic acids are chains of nucleotides that are a vital part of all living beings. The two most common types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), which provide ...

What are spherical nucleic acids (SNAs)? What do they consist of and how do they differ from linear nucleic acids? Spherical nucleic acids are structures that are made by taking a nanoparticle ...

Our research focuses on all aspects of nucleic acid structure, chemistry and function employing state of the art technologies and approaches. The structure and chemistry of nucleic acids is ...

DNA is the poster child for high-specificity binding. As long as their base sequences match, two complementary strands of DNA can navigate through a sea of biomolecules, find each other, and hold fast ...

The research focus of the Müller group is the bioinorganic chemistry of nucleic acids with a particular emphasis on the generation, characterization as well as application of nucleic acids including ...

Nucleic acids such as DNA and RNA play a central role in gene therapies and vaccines. They store and transmit biological information. In order for them to work in the body, they must enter the cells ...

Quantification of nucleic acid concentrations is often performed by measuring light absorption in UV-VIS spectrometers. There are a few challenges faced in this measurement method. In UV-VIS ...