A new research paper was published in Oncotarget on August 3, 2022, entitled, "A novel mechanism of regulation of the oncogenic transcription factor GLI3 by toll-like receptor signaling." The ...

Establishment of the Immunotoxicity AOP Framework: The binding of PCP to TLR5 was identified as the molecular initiating event. This event triggers a series of key events, activation of the TLR ...

On immune cells, Toll-like receptors are capable of detecting infections just like a sniffer dog, using special sensors known as Toll-like receptors, or TLRs for short. But what signals activate TLRs, ...

Researchers at Brigham and Women’s Hospital have identified a new class of small molecules that selectively shut down ...